Does the cranial mesenchyme contribute to neural fold elevation during neurulation?
نویسندگان
چکیده
منابع مشابه
The Role of the Mesenchyme in Mouse Neural Fold Elevation
Hyaluronate (HA) distribution patterns were examined in the cranial mesenchyme underlying the mesencephalic neural folds of mouse embryos maintained in roller tube culture. Using standard image-processing techniques, the digitized images of Alcian blue-stained or 3H-glucosamine-labeled sections digested with an enzyme specific for HA, were subtracted from adjacent, undigested sections. The resu...
متن کاملAn Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme
The central nervous system is derived from the neural plate that undergoes a series of complex morphogenetic movements resulting in formation of the neural tube in a process known as neurulation. During neurulation, morphogenesis of the mesenchyme that underlies the neural plate is believed to drive neural fold elevation. The cranial mesenchyme is comprised of the paraxial mesoderm and neural c...
متن کاملThe kinetic behaviour of the cranial neural epithelium during neurulation in the rat.
The kinetic behaviour of the cranial neuroepithelial cells of rat embryos during neurulation is described. Serial transverse sections of 4-, 8-, 12- and 16-somite-stage embryos show that differential mitosis does not play a part in the mechanisms responsible for effecting cranial neural tube closure. A constant cell number is found in the midbrain/hindbrain neural epithelium during all four sta...
متن کاملGrowth and development of pattern in the cranial neural epithelium of rat embryos during neurulation.
The pattern of growth and morphogenesis of the cranial neural epithelium of rat embryos during neurulation is described. Transverse sections of the midbrain/hindbrain neural epithelium at different stages (0-14 somites) show a constant area and cell number throughout neurulation, even though there is a high level of mitosis. Mitotic spindles are orientated parallel to the long axis of the embry...
متن کاملHectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme
Hectd1 mutant mouse embryos exhibit the neural tube defect exencephaly associated with abnormal cranial mesenchyme. Cellular rearrangements in cranial mesenchyme are essential during neurulation for elevation of the neural folds. Here we investigate the molecular basis of the abnormal behavior of Hectd1 mutant cranial mesenchyme. We demonstrate that Hectd1 is a functional ubiquitin ligase and t...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2012
ISSN: 1542-0752
DOI: 10.1002/bdra.23073